LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

@article{Quadri2018LRP10,
  title={
 LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study},
  author={Marialuisa Quadri and Wim Mandemakers and Martyna M. Grochowska and Roy G Masius and Piero Parchi and International Parkinsonism Genetics Network},
  journal={The Lancet Neurology},
  year={2018},
  volume={17},
  pages={597-608}
}

The role of genetics in Parkinson's disease: a large cohort study in Chinese mainland population.

TLDR
The data highlight the importance of genetic testing in Parkinson's disease patients with age at onset < 40 years, especially in those from families with a recessive inheritance pattern, who may benefit from early diagnosis and treatment.

Screening of LRP10 mutations in Parkinson's disease patients from Italy.

LRP10: A novel disease gene bridging Parkinson's disease and dementia with Lewy body

  • F. MorganteE. Valente
  • Biology, Medicine
    Movement disorders : official journal of the Movement Disorder Society
  • 2019
TLDR
Although its function is largely unknown, LRP10 has been implicated in trafficking between the transGolgi network and endosomes and could be involved in the regulation of α-synuclein aggregation and cell-to-cell transmission, opening novel intriguing windows on the pathogenetic mechanisms underlying these disorders.

Genetics of Parkinson's disease

TLDR
A comprehensive overview on PD genetics is provided to provide a comprehensive overview of the genetic architecture underlying this disease as families harboring rare genetic variants are sparse and globally widespread.

Clinical and Pathological Phenotypes of LRP10 Variant Carriers with Dementia

TLDR
Findings suggest a role for LRP10 across a broad neurodegenerative spectrum as well as some patients with dementia and different brain pathologies including DLB, mixed AD/LBD, and AD.

Analysis of the LRP10 gene in patients with Parkinson’s disease and dementia with Lewy bodies from Southern Italy

Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies (DLB). The aim of the present study was to evaluate
...

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