LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

@article{Quadri2018LRP10GV,
  title={LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study},
  author={M. Quadri and Wim Mandemakers and Martyna M Grochowska and R. Masius and Piero Parchi and International Parkinsonism Genetics Network},
  journal={The Lancet Neurology},
  year={2018},
  volume={17},
  pages={597-608}
}
  • M. Quadri, Wim Mandemakers, +3 authors International Parkinsonism Genetics Network
  • Published 2018
  • Medicine
  • The Lancet Neurology
  • BACKGROUND Most patients with Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies do not carry mutations in known disease-causing genes. The aim of this study was to identify a novel gene implicated in the development of these disorders. METHODS Our study was done in three stages. First, we did genome-wide linkage analysis of an Italian family with dominantly inherited Parkinson's disease to identify the disease locus. Second, we sequenced the candidate gene in an… CONTINUE READING
    43 Citations
    A novel link between trafficking and Lewy body disorders
    LRP10: A novel disease gene bridging Parkinson's disease and dementia with Lewy body
    Genetics of Parkinson's disease
    Clinical and Pathological Phenotypes of LRP10 Variant Carriers with Dementia
    The genetic landscape of Parkinson's disease.
    • 54

    References

    SHOWING 1-10 OF 39 REFERENCES
    VPS35 mutations in Parkinson disease.
    • 659
    • PDF
    Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.
    • 715
    • PDF
    The genetics of Parkinson's disease: Progress and therapeutic implications
    • 301
    Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
    • 7,976
    • PDF