LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein.

@article{Parkyn2008LRP1CB,
  title={LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein.},
  author={Celia J Parkyn and Esmeralda G.M. Vermeulen and Roy C. Mootoosamy and Claire Sunyach and Christian Jacobsen and Claus Oxvig and S\oren K Moestrup and Qiang Liu and Guojun Bu and Angela Y T Jen and Roger J. Morris},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 6},
  pages={773-83}
}
The trafficking of normal cellular prion protein (PrPC) is believed to control its conversion to the altered conformation (designated PrPSc) associated with prion disease. Although anchored to the membrane by means of glycosylphosphatidylinositol (GPI), PrPC on neurons is rapidly and constitutively endocytosed by means of coated pits, a property dependent upon basic amino acids at its N-terminus. Here, we show that low-density lipoprotein receptor-related protein 1 (LRP1), which binds to… CONTINUE READING