LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.


The pathogenesis of Alzheimer's disease (AD) involves the abnormal accumulation and deposition of beta-amyloid in cerebral blood vessels and in the brain parenchyma. Critical in modulating beta-amyloid deposition in brain is the flux of Abeta across the blood brain barrier. The low-density lipoprotein receptor-related protein (LRP), is a large endocytic… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.