LRP in amyloid-beta production and metabolism.

  title={LRP in amyloid-beta production and metabolism.},
  author={Guojun Bu and Judy A Cam and Celina V. Zerbinatti},
  journal={Annals of the New York Academy of Sciences},
Amyloid-beta peptide (Abeta) production and accumulation in the brain is a central event in the pathogenesis of Alzheimer's disease (AD). Recent studies have shown that apolipoprotein E (apoE) receptors, members of the low-density lipoprotein receptor (LDLR) family, modulate Abeta production as well as Abeta cellular uptake. Abeta is derived from proteolytic processing of the amyloid precursor protein (APP), which interacts with several members of the LDLR family. Studies from our laboratory… CONTINUE READING
46 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 46 extracted citations

Similar Papers

Loading similar papers…