LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis

  title={LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis},
  author={Nicolas Etique and Laurie Verzeaux and St{\'e}phane Dedieu and Herv{\'e} Emonard},
  booktitle={BioMed research international},
Low-density lipoprotein receptor-related protein-(LRP-1) is a large endocytic receptor that binds more than 35 ligands and exhibits signaling properties. Proteinases capable of degrading extracellular matrix (ECM), called matrix proteinases in this paper, are mainly serine proteinases: the activators of plasminogen into plasmin, tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, and the members of the matrix metalloproteinase (MMP) family. LRP-1 is responsible for clearing… CONTINUE READING