LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation.

@article{Neuill2015LRIT3IE,
  title={LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation.},
  author={Marion Neuill{\'e} and Catherine W. Morgans and Yan Cao and Elise Orhan and Christelle Michiels and J. Sahel and Isabelle Audo and Robert M. Duvoisin and Kirill A Martemyanov and Christina Zeitz},
  journal={The European journal of neuroscience},
  year={2015},
  volume={42 3},
  pages={1966-75}
}
Mutations in LRIT3 lead to complete congenital stationary night blindness (cCSNB). The exact role of LRIT3 in ON-bipolar cell signaling cascade remains to be elucidated. Recently, we have characterized a novel mouse model lacking Lrit3 [no b-wave 6, (Lrit3(nob6/nob6) )], which displays similar abnormalities to patients with cCSNB with LRIT3 mutations. Here we compare the localization of components of the ON-bipolar cell signaling cascade in wild-type and Lrit3(nob6/nob6) retinal sections by… CONTINUE READING
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