LRH-1-dependent glucose sensing determines intermediary metabolism in liver.


Liver receptor homolog 1 (LRH-1), an established regulator of cholesterol and bile acid homeostasis, has recently emerged as a potential drug target for liver disease. Although LRH-1 activation may protect the liver against diet-induced steatosis and insulin resistance, little is known about how LRH-1 controls hepatic glucose and fatty acid metabolism under… (More)
DOI: 10.1172/JCI62368


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@article{Oosterveer2012LRH1dependentGS, title={LRH-1-dependent glucose sensing determines intermediary metabolism in liver.}, author={Maaike H. Oosterveer and Chikage Mataki and Hiroyasu Yamamoto and Taoufiq Harach and Norman Moullan and Theo H. van Dijk and Eduard Ayuso and Fatima Bosch and Catherine Postic and Albert K. Groen and Johan Auwerx and Kristina Schoonjans}, journal={The Journal of clinical investigation}, year={2012}, volume={122 8}, pages={2817-26} }