LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression

@article{Bianco2015LRH1CP,
  title={LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression},
  author={St{\'e}phanie Bianco and Ma{\"i}ka Jangal and Daniel Garneau and Nicolas Gevry},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={4509-4518}
}
Liver receptor homolog-1 (LRH-1, NR5A2) is an orphan nuclear receptor that has an essential role in cancer progression, notably in breast cancer. Although its role in promoting cancer cell proliferation and migration is well documented, the molecular basis is not completely established. Here, we report that LRH-1 inhibition affects two- and three-dimensional cell proliferation of different types of breast cancer cells, including estrogen receptor α (ERα)-positive and triple-negative cells. This… CONTINUE READING
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