LRET investigations of conformational changes in the ligand binding domain of a functional AMPA receptor.

@article{Gonzalez2008LRETIO,
  title={LRET investigations of conformational changes in the ligand binding domain of a functional AMPA receptor.},
  author={Jennifer M. Reingle Gonzalez and Anu Rambhadran and Mei Du and Vasanthi Jayaraman},
  journal={Biochemistry},
  year={2008},
  volume={47 38},
  pages={10027-32}
}
The structural investigations using the soluble ligand binding domain of the AMPA subtype of the glutamate receptor have provided invaluable insight into the mechanistic pathway by which agonist binding to this extracellular domain mediates the formation of cation-selective channels in this protein. These structures, however, are in the absence of the transmembrane segments, the primary functional component of the protein. Here, we have used a modified luminescence resonance energy transfer… CONTINUE READING