LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells.

@article{Smirnova2003LPSUM,
  title={LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells.},
  author={Marina G Smirnova and Li Guo and John P. Birchall and Jeffrey Peter Pearson},
  journal={Cellular immunology},
  year={2003},
  volume={221 1},
  pages={
          42-9
        }
}
Bacterial inflammation in mucosa is accompanied by morphological and proliferative changes in goblet cells and mucin hypersecretion. Main stimulators of bacterial inflammation are bacterial lipopolysaccharides (LPS). In vitro investigation of the LPS effect on the molecular processes in goblet cells, using the human mucin-secreting goblet cell line HT29-MTX, showed the following results. LPS up-regulated mucin and cytokine mRNA expression and secretion in goblet cells in a concentration and… CONTINUE READING
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