LPS-stimulated inflammation inhibits BMP-9-induced osteoblastic differentiation through crosstalk between BMP/MAPK and Smad signaling.

@article{Daigang2016LPSstimulatedII,
  title={LPS-stimulated inflammation inhibits BMP-9-induced osteoblastic differentiation through crosstalk between BMP/MAPK and Smad signaling.},
  author={Lu Daigang and Qu Jining and Lei Jinlai and Wang Pengfei and Sun Chuan and Huang Liangku and Tian Ding and Song Zhe and Wenli Wei and Li Zhong and Zhang Kun},
  journal={Experimental cell research},
  year={2016},
  volume={341 1},
  pages={
          54-60
        }
}
Inflammation is a common situation during bone healing and is recognized to inhibit osteogenic differentiation and bone formation. However, the effect of inflammation on BMP-9-induced osteoblastic differentiation remains unclear. In the present study, we found that an inflammatory environment triggered by lipopolysaccharide (LPS) in vitro suppressed BMP-9-induced osteogenic differentiation. In addition, LPS decreased BMP-9-induced phosphorylation of Smad1/5/8 and showed obvious inhibitory… CONTINUE READING

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Silencing of Long Non-Coding RNA NONHSAT009968 Ameliorates the Staphylococcal Protein A-Inhibited Osteogenic Differentiation in Human Bone Mesenchymal Stem Cells.

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