LPS reduces HIV-1 replication in primary human macrophages partly through an endogenous production of type I interferons.

@article{Simard2008LPSRH,
  title={LPS reduces HIV-1 replication in primary human macrophages partly through an endogenous production of type I interferons.},
  author={S{\'e}bastien Simard and Emilie Maurais and Caroline Gilbert and Michel J Tremblay},
  journal={Clinical immunology},
  year={2008},
  volume={127 2},
  pages={198-205}
}
It has been proposed that the systemic immune activation state seen in HIV-1-infected patients is caused by circulating microbial products such as lipopolysaccharide (LPS). Given that macrophages play a key role in HIV-1 pathogenesis, we investigated the LPS-mediated effect on HIV-1 replication in cells of the myeloid lineage. We demonstrate that LPS promotes virus gene expression in a monocytic cell line while it diminishes virus production in primary human monocyte-derived macrophages (MDM… CONTINUE READING
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