LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b

@inproceedings{Ti2015LPSpreconditionedMS,
  title={LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b},
  author={Dongdong Ti and Haojie Hao and Chuan Tong and Jiejie Liu and Liang Dong and Jingxi Zheng and Yali Zhao and Huiling Liu and Xiaobing Fu and Weidong Han},
  booktitle={Journal of Translational Medicine},
  year={2015}
}
Within the last few years, it has become evident that LPS-preconditioned mesenchymal stromal cells (LPS pre-MSCs) show enhanced paracrine effects, including increased trophic support and improved regenerative and repair properties. MSCs may release large amounts of exosomes for cell-to-cell communication and maintain a dynamic and homeostatic microenvironment for tissue repair. The present study assesses the therapeutic efficacy and mechanisms of LPS-preconditioned MSC-derived exosomes (LPS pre… CONTINUE READING
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