LPS-mediated NF-kappa beta activation in rat Kupffer cells can be induced independently of CD14.

@article{Bellezzo1996LPSmediatedNB,
  title={LPS-mediated NF-kappa beta activation in rat Kupffer cells can be induced independently of CD14.},
  author={Joseph M Bellezzo and Robert S. Britton and Bruce R. Bacon and Erika Schwenn Fox},
  journal={The American journal of physiology},
  year={1996},
  volume={270 6 Pt 1},
  pages={G956-61}
}
Lipopolysaccharide (LPS) activation of macrophages occurs after LPS complexed with serum LPS-binding protein (LBP) binds CD14. Activation of the nuclear transcription factor NF-kappa B is directly related to this event. Since the role of CD14 in LPS signaling has not been evaluated in Kupffer cells, the resident hepatic macrophage, the purpose of this study was to characterize LPS-mediated NF-kappa B activation under CD14-dependent (1% serum, as a source of LBP) and CD14-independent (serum-free… CONTINUE READING

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