LPS induces the TNF-alpha-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis.

@article{Lehmann2008LPSIT,
  title={LPS induces the TNF-alpha-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis.},
  author={Guillermo Luis Lehmann and F. Torres i Carreras and Leandro Raul Soria and Sergio A. Gradilone and Ra{\'u}l Alberto Marinelli},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={294 2},
  pages={
          G567-75
        }
}
Although bacterial lipopolysaccharides (LPS) are known to cause cholestasis in sepsis, the molecular mechanisms accounting for this effect are only partially known. Because aquaporin-8 (AQP8) seems to facilitate the canalicular osmotic water movement during hepatocyte bile formation, we studied its gene and functional expression in LPS-induced cholestasis. By subcellular fractionation and immunoblotting analysis, we found that 34-kDa AQP8 was significantly decreased by 70% in plasma… CONTINUE READING
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