LPS induces the TNF-alpha-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis.

Abstract

Although bacterial lipopolysaccharides (LPS) are known to cause cholestasis in sepsis, the molecular mechanisms accounting for this effect are only partially known. Because aquaporin-8 (AQP8) seems to facilitate the canalicular osmotic water movement during hepatocyte bile formation, we studied its gene and functional expression in LPS-induced cholestasis… (More)
DOI: 10.1152/ajpgi.00232.2007

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Cite this paper

@article{Lehmann2008LPSIT, title={LPS induces the TNF-alpha-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis.}, author={Guillermo Luis Lehmann and Flavia I Carreras and Leandro Raul Soria and Sergio A. Gradilone and Ra{\'u}l Alberto Marinelli}, journal={American journal of physiology. Gastrointestinal and liver physiology}, year={2008}, volume={294 2}, pages={G567-75} }