LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha.

@article{Xaus2000LPSIA,
  title={LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha.},
  author={Jordi Xaus and M{\'o}nica Comalada and Annabel F. Valledor and Jorge Lloberas and Fernando L{\'o}pez-Soriano and Josep Maria Argil{\'e}s and Christian Bogdan and Antonio Celada},
  journal={Blood},
  year={2000},
  volume={95 12},
  pages={3823-31}
}
The deleterious effects of lipopolysaccharide (LPS) during endotoxic shock are associated with the secretion of tumor necrosis factor (TNF) and the production of nitric oxide (NO), both predominantly released by tissue macrophages. We analyzed the mechanism by which LPS induces apoptosis in bone marrow-derived macrophages (BMDM). LPS-induced apoptosis reached a plateau at about 6 hours of stimulation, whereas the production of NO by the inducible NO-synthase (iNOS) required between 12 and 24… CONTINUE READING