LPS induces CD 40 gene expression through the activation of NF-B and STAT-1 in macrophages and microglia

@inproceedings{Qin2005LPSIC,
  title={LPS induces CD 40 gene expression through the activation of NF-B and STAT-1 in macrophages and microglia},
  author={Hongwei Qin and Cynthia A. Wilson and Xueyan Zhao and Etty Tika N Benveniste},
  year={2005}
}
CD40 is expressed on various immune cells, including macrophages and microglia. Aberrant expression of CD40 is associated with autoimmune inflammatory diseases such as multiple sclerosis and rheumatoid arthritis. Interaction of Tolllike receptor-4 (TLR4) with the Gramnegative bacteria endotoxin lipopolysaccharide (LPS) results in the induction of an array of immune response genes. In this study, we describe that LPS is a strong inducer of CD40 expression in macrophages and microglia, which… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 44 references

CD40: a growing cytoplasmic tale.

Science's STKE : signal transduction knowledge environment • 2004

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