LPS-induced oxidative stress and inflammatory reaction in the rat striatum.

@article{NoworytaSokoowska2013LPSinducedOS,
  title={LPS-induced oxidative stress and inflammatory reaction in the rat striatum.},
  author={Karolina Noworyta-Sokołowska and Anna G{\'o}rska and Krystyna Gołembiowska},
  journal={Pharmacological reports : PR},
  year={2013},
  volume={65 4},
  pages={
          863-9
        }
}
BACKGROUND Inflammation-induced microglia activation and increased oxidative stress have been observed in neurodegenerative disorders, such as Parkinson's disease. The aim of our study was to determine the appropriate dose and route of LPS administration to study hydroxyl radical generation and extracellular level of dopamine (DA), glutamate (GLU) and adenosine (ADN) in the rat striatum as markers of DA neuron damage and glial cell activation. The effect of LPS administration on DA, DOPAC, HVA… CONTINUE READING

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