LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor.

@article{Nowak2000LPSinducedLI,
  title={LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor.},
  author={Maciek A. Nowak and Gregory C Gaines and Jason J. Rosenberg and Ralph R Minter and Frances Rena Bahjat and John E. Rectenwald and Sally L. D. Mackay and Carl Keith Edwards and Lyle L. Moldawer},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={278 5},
  pages={
          R1202-9
        }
}
Lipopolysaccharide and D-galactosamine induced lethality and apoptotic liver injury is dependent on endogenously produced tumor necrosis factor (TNF)-alpha. The present study was undertaken to determine whether membrane-associated or secreted TNF-alpha signaling through the p55 or p75 receptor was responsible for survival and hepatic injury after lipopolysaccharide administration in D-galactosamine-sensitized mice. Transgenic mice expressing null forms of TNF-alpha, the p55 and p75 receptor… CONTINUE READING
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