LPS-induced down-regulation of signal regulatory protein α contributes to innate immune activation in macrophages

Abstract

JEM © The Rockefeller University Press $30.00 Vol. 204, No. 11, October 29, 2007 2719-2731 www.jem.org/cgi/doi/ 2719 10.1084/jem.20062611 The innate immune system is evolutionally conserved, and it is the fi rst line of the defensive mechanisms for protecting the host from invading microbial pathogens ( 1 ). Innate immune cells, including macrophages and… (More)

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