LPS-induced cytokine production in human monocytes and macrophages.

  title={LPS-induced cytokine production in human monocytes and macrophages.},
  author={Manuela Rossol and Holger Heine and Undine Meusch and Dagmar Quandt and Carina Klein and Matthew J Sweet and Sunna Hauschildt},
  journal={Critical reviews in immunology},
  volume={31 5},
Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate immune-activating stimuli known. Here we review the current understanding of LPS effects on human monocyte and macrophage function. We provide an overview of LPS signal transduction with attention given to receptor cooperativity and species differences in LPS responses, as well as the role of tyrosine phosphorylation and lysine acetylation in signalling. We also review LPS-regulated transcription, with… CONTINUE READING
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