LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice.

@article{Faggioni1997LPSinducedAI,
  title={LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice.},
  author={Raffaella Faggioni and John Fuller and Arthur H. Moser and Kenneth R. Feingold and Carl Grunfeld},
  journal={The American journal of physiology},
  year={1997},
  volume={273 1 Pt 2},
  pages={R181-6}
}
Administration of endotoxin (lipopolysaccharide, LPS) induces profound anorexia. Injection of leptin decreases food intake in mice. Recently, we reported that LPS and cytokines increase leptin levels in hamsters. To further investigate the role of leptin in the LPS-induced anorexia, we administered LPS to leptin receptor-deficient (db/db) and leptin-deficient (ob/ob) mice. We found that LPS caused anorexia in both db/db and ob/ob mice. As might be predicted if leptin had a role in anorexia, the… CONTINUE READING