LPS independent activation of the pro-inflammatory receptor Trem1 by C/EBPε in granulocytes

@inproceedings{Suh2017LPSIA,
  title={LPS independent activation of the pro-inflammatory receptor Trem1 by C/EBPε in granulocytes},
  author={Hyung Chan Suh and Touati Benoukraf and Pavithra Shyamsunder and Tong Yin and Qi Cao and Jonathan W Said and Stephen D. Lee and Ricky Yee Meng Lim and Henry Yang and Jacqueline Salotti and Peter F. Johnson and Vikas Madan and H. Phillip Koeffler},
  booktitle={Scientific reports},
  year={2017}
}
C/EBPε is a critical transcriptional factor for granulocyte differentiation and function. Individuals with germline mutations of C/EBPε fail to develop normal granulocytes and suffer from repeated infections. In order to gain a global view of the transcriptional machinery regulated by C/EBPε, we performed whole-genome ChIP-Seq using mouse bone marrow cells. To complement the C/EBPε DNA binding analyses, RNA-Sequencing was done in parallel using sorted mature and immature granulocytes from WT… CONTINUE READING
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