LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4

@article{Bihl2001LPShyporesponsivenessOM,
  title={LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4},
  author={Franck Bihl and Laurent Larivi{\`e}re and S Qureshi and Lorraine Flaherty and Danielle Malo},
  journal={Genes and Immunity},
  year={2001},
  volume={2},
  pages={56-59}
}
Toll-like receptors (Tlrs) are transmembrane proteins that have recently been shown to play a critical role in the innate immune recognition of microbial constituents. Among this family, Tlr4 is a crucial signal transducer for lipopolysaccharide (LPS), the major component of the Gram-negative bacteria outer cell membrane. In this paper, we report that C57BL/6.KB2-mnd mice, a model of neuronal ceroid lipofuscinosis, do not respond to LPS. This defect is associated with a spontaneous mutation in… CONTINUE READING

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