LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling.


Among the many inflammatory mediators induced by the prototypical inflammatory stimulus lipopolysaccharide (LPS), which signals via Toll-like receptor (TLR)-4, interleukin (IL)-6 has recently been shown to feedback and augment TLR4 signaling when overproduced in LPS hypersensitive gp130(F/F) mice. This regulation by IL-6 in gp130(F/F) mice requires… (More)
DOI: 10.1038/icb.2011.56


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