LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling.

Abstract

Among the many inflammatory mediators induced by the prototypical inflammatory stimulus lipopolysaccharide (LPS), which signals via Toll-like receptor (TLR)-4, interleukin (IL)-6 has recently been shown to feedback and augment TLR4 signaling when overproduced in LPS hypersensitive gp130(F/F) mice. This regulation by IL-6 in gp130(F/F) mice requires… (More)
DOI: 10.1038/icb.2011.56

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