LPS depletes PHLPP levels in macrophages through the inhibition of SP1 dependent transcriptional regulation.

@article{AlamuruYellapragada2017LPSDP,
  title={LPS depletes PHLPP levels in macrophages through the inhibition of SP1 dependent transcriptional regulation.},
  author={Neeraja P Alamuru-Yellapragada and Sanghamitra Vundyala and Soma Behera and Kishore V. L. Parsa},
  journal={Biochemical and biophysical research communications},
  year={2017},
  volume={486 2},
  pages={533-538}
}
We have previously reported that bacterial endotoxin LPS attenuates expression of PHLPP, a ser/thr phosphatase, at both transcript and protein levels in different immune cells, however the underlying molecular mechanism is unknown and is of significant interest. Here, in line with the decreased transcript levels upon LPS treatment, we observed that LPS caused significant reduction in PHLPP promoter activity. We observed that SP1, a transcription factor frequently associated with inflammation… CONTINUE READING