LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney*

@article{Feingold2008LPSDF,
  title={LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney*},
  author={Kenneth R. Feingold and Yuwei Wang and Arthur H. Moser and Judy K. Shigenaga and Carl Grunfeld},
  journal={Journal of Lipid Research},
  year={2008},
  volume={49},
  pages={2179 - 2187}
}
Inflammation produces marked changes in lipid metabolism, including increased serum fatty acids (FAs) and triglycerides (TGs), increased hepatic TG production and VLDL secretion, increased adipose tissue lipolysis, and decreased FA oxidation in liver and heart. Lipopolysaccharide (LPS) also increases TG and cholesteryl ester levels in kidneys. Here we confirm these findings and define potential mechanisms. LPS decreases renal FA oxidation by 40% and the expression of key proteins required for… CONTINUE READING

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