LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF


Toll–IL-1–resistance (TIR) domain–containing adaptor-inducing IFN(TRIF)–related adaptor molecule (TRAM) is the fourth TIR domain–containing adaptor protein to be described that participates in Toll receptor signaling. Like TRIF, TRAM activates interferon regulatory factor (IRF)-3, IRF-7, and NFB-dependent signaling pathways. Toll-like receptor (TLR)3 and 4… (More)


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