LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis

Abstract

Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease for which there are no effective therapies. Patients with AH show impaired hepatocyte proliferation, expansion of inefficient ductular cells and high lipopolysaccharide (LPS) levels. It is unknown whether LPS mediates ductular cell expansion. We performed transcriptome studies and… (More)
DOI: 10.1038/srep35610

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