LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells

@inproceedings{Yukiura2015LPP3LL,
  title={LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells},
  author={Hiroshi Yukiura and Kuniyuki Kano and Ryoji Kise and Asuka Inoue and Junken Aoki},
  booktitle={Journal of cell science},
  year={2015}
}
Lysophosphatidic acid (LPA) is emerging as an angiogenic factor, because knockdown of the enzyme that produces it (autotaxin, also known as ENPP2) and its receptors cause severe developmental vascular defects in both mice and fish. In addition, overexpression of autotaxin in mice causes similar vascular defects, indicating that the extracellular amount of LPA must be tightly regulated. Here, we focused on an LPA-degrading enzyme, lipid phosphate phosphatase 3 (LPP3, also known as PPAP2B), and… CONTINUE READING
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