LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury.

@article{Gorenne2006LPPED,
  title={LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury.},
  author={Isabelle Gorenne and Lu Jin and Tadashi Yoshida and John M Sanders and Ian J. Sarembock and Gary K. Owens and Andrew P. Somlyo and Avril V. Somlyo},
  journal={Circulation research},
  year={2006},
  volume={98 3},
  pages={378-85}
}
Lipoma preferred partner (LPP) has been identified as a protein highly expressed in smooth muscle (SM) tissues. The aim of the present study was to determine mechanisms that regulate LPP expression in an in vitro model of SM cell (SMC) differentiation and in stent-induced pig coronary vessel injury. All trans-retinoic acid treatment of A404 cells induced a strong increase in LPP, as well as SM alpha-actin, SM myosin heavy chain, and smoothelin mRNA levels, in a Rho kinase (ROK)-dependent manner… CONTINUE READING

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