LPL polymorphism (D9N) predicts cardiovascular disease risk directly and through interaction with CETP polymorphism (TaqIB) in women with high HDL cholesterol and CRP.

@article{Corsetti2011LPLP,
  title={LPL polymorphism (D9N) predicts cardiovascular disease risk directly and through interaction with CETP polymorphism (TaqIB) in women with high HDL cholesterol and CRP.},
  author={James P. Corsetti and Ronald T. Gansevoort and Gerjan Navis and Charles E. Sparks and Robin P. F. Dullaart},
  journal={Atherosclerosis},
  year={2011},
  volume={214 2},
  pages={373-6}
}
OBJECTIVE We sought to determine whether concurrently high levels of HDL cholesterol and CRP predict initial cardiovascular events in women, and to assess additional risk involving two genes encoding proteins involved in reverse cholesterol transport. METHODS A graphical approach identified high-risk subgroups in a population-based female cohort. Polymorphism-associated risk was assessed for CETP (TaqIB [rs708272]) and LPL (D9N [rs1801177]) using multivariable analysis adjusted for clinical… CONTINUE READING