LPK-26, a novel kappa-opioid receptor agonist with potent antinociceptive effects and low dependence potential.

@article{Tao2008LPK26AN,
  title={LPK-26, a novel kappa-opioid receptor agonist with potent antinociceptive effects and low dependence potential.},
  author={Yi-min Tao and Qing-Lin Li and Cong-Fen Zhang and Xue-jun Xu and Jie Chen and Ya-Wen Ju and Zhi-qiang Chi and Ya-Qiu Long and Jing-Gen Liu},
  journal={European journal of pharmacology},
  year={2008},
  volume={584 2-3},
  pages={306-11}
}
Analgesics such as morphine cause many side effects including addiction, but kappa-opioid receptor agonist can produce antinociception without morphine-like side effects. With the aim of developing new and potent analgesics with lower abuse potential, we studied the antinociceptive and physical dependent properties of a derivate of ICI-199441, an analogue of (-)U50,488H, named (2-(3,4-dichloro)-phenyl)-N-methyl-N-[(1S)-1-(2-isopropyl)-2-(1-(3-pyrrolinyl))ethyl] acetamides (LPK-26). LPK-26… CONTINUE READING
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