LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.

@article{Kang2008LPIN1GV,
  title={LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.},
  author={Eun Seok Kang and Se Eun Park and Seung Jin Han and So Hun Kim and Chung Mo Nam and Chul Woo Ahn and Bong Soo Cha and Kyung Sub Kim and Hyun Chul Lee},
  journal={Molecular genetics and metabolism},
  year={2008},
  volume={95 1-2},
  pages={96-100}
}
Lipin1 protein, a product of the LPIN1 gene, is required for normal adipose tissue development and metabolism. Lipin1 deficiency results in immature adipocyte development in cases of mouse fatty liver dystrophy and human lipodystrophy. Recently, pioglitazone has been reported to increase human adipocyte lipin1 expression. We evaluated the effects of LPIN1 polymorphisms on rosiglitazone response in patients with type 2 diabetes (T2DM). A total of 262 patients were treated with 12 weeks of… CONTINUE READING