LPHN3 and attention-deficit/hyperactivity disorder: a susceptibility and pharmacogenetic study.

  title={LPHN3 and attention-deficit/hyperactivity disorder: a susceptibility and pharmacogenetic study.},
  author={Estela Maria Bruxel and Ang{\'e}lica Salatino-Oliveira and Glaucia Chiyoko Akutagava-Martins and Luciana Tovo-Rodrigues and J{\'u}lia Pasqualini Genro and Cristian P. Zeni and Guilherme Vanoni Polanczyk and Rodrigo Chazan and Marcelo Schmitz and Mauricio Arcos-Burgos and Luis Augusto Rohde and Mara H Hutz},
  journal={Genes, brain, and behavior},
  volume={14 5},
Latrophilin 3 (LPHN3) is a brain-specific member of the G-protein coupled receptor family associated to both attention-deficit/hyperactivity disorder (ADHD) genetic susceptibility and methylphenidate (MPH) pharmacogenetics. Interactions of LPHN3 variants with variants harbored in the 11q chromosome improve the prediction of ADHD development and medication response. The aim of this study was to evaluate the role of LPHN3 variants in childhood ADHD susceptibility and treatment response in a… CONTINUE READING
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A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to Genes, Brain and Behavior

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