LPA2 receptor mediates mitogenic signals in human colon cancer cells.

  title={LPA2 receptor mediates mitogenic signals in human colon cancer cells.},
  author={C H Chris Yun and Hong Sun and Dongsheng Wang and Raluca Rusovici and Amanda M. Castleberry and Randy A Hall and Hyunsuk Shim},
  journal={American journal of physiology. Cell physiology},
  volume={289 1},
Lysophosphatidic acid (LPA) is a mediator of multiple cellular responses. LPA mediates its effects predominantly through the G protein-coupled receptors LPA1, LPA2, and LPA3. In the present work, we studied LPA2-mediated signaling using human colon cancer cell lines, which predominantly express LPA2. LPA2 activated Akt and Erk1/2 in response to LPA. LPA mediated Akt activation was inhibited by pertussis toxin (PTX), whereas Erk1/2 activation was completely inhibited by a blocker of… CONTINUE READING


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