LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs

@article{Mori2015LPAST,
  title={LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs},
  author={Shiori Mori and Mutsumi Araki and Shuhei Ishii and Miku Hirane and Kaori Fukushima and Ayaka Tomimatsu and Kaede Takahashi and Nobuyuki Fukushima and Toshifumi Tsujiuchi},
  journal={Molecular and Cellular Biochemistry},
  year={2015},
  volume={408},
  pages={147-154}
}
Lysophosphatidic acid (LPA) signaling via LPA receptors provides a variety of cellular functions, including angiogenesis. In this study, to assess an involvement of LPA receptors in cell motile activities of endothelial cells during chemotherapy, F-2 cells were treated with cisplatin (CDDP) and doxorubicin (DOX) at a concentration of 0.01 μM every 24 h for at least 1 month. The treatment of CDDP and DOX inhibited the expression levels of the LPA receptor-1 (Lpar1), Lpar2, and Lpar3 genes in F-2… CONTINUE READING
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