LPA receptors: subtypes and biological actions.

  title={LPA receptors: subtypes and biological actions.},
  author={Ji woong Choi and Deron R Herr and Kyoko Noguchi and Yun C Yung and Chang-Wook Lee and Tetsuji Mutoh and Mu-En Lin and Siew Teng Teo and Kristine E Park and Alycia N Mosley and Jerold Chun},
  journal={Annual review of pharmacology and toxicology},
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular signaling molecule by binding to and activating at least five known G protein-coupled receptors (GPCRs): LPA(1)-LPA(5). They are encoded by distinct genes named LPAR1-LPAR5 in humans and Lpar1-Lpar5 in mice. The biological roles of LPA are diverse and include developmental, physiological, and pathophysiological effects. This diversity is mediated by broad and overlapping expression patterns and… CONTINUE READING
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