LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.

@article{Ward2011LPARH,
  title={LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.},
  author={Yvona Ward and Ross Lake and Juan Yin and Christopher D. Heger and Mark A. Raffeld and Paul K. Goldsmith and Mar{\'i}a S Caceres Merino and Kathleen Kelly},
  journal={Cancer research},
  year={2011},
  volume={71 23},
  pages={7301-11}
}
CD97, an adhesion-linked G-protein-coupled receptor (GPCR), is induced in multiple epithelial cancer lineages. We address here the signaling properties and the functional significance of CD97 expression in prostate cancer. Our findings show that CD97 signals through Gα12/13 to increase RHO-GTP levels. CD97 functioned to mediate invasion in prostate cancer cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1), leading to enhanced LPA-dependent RHO and… CONTINUE READING
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