LPA is a novel lipid regulator of mesangial cell hexokinase activity and HKII isoform expression.

@article{Coy2002LPAIA,
  title={LPA is a novel lipid regulator of mesangial cell hexokinase activity and HKII isoform expression.},
  author={Platina E Coy and Navin Taneja and Iris Fung Kam Lee and Claudie M Hecquet and Jane M Bryson and Robert Robey},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={283 2},
  pages={F271-9}
}
The prototypical extracellular phospholipid mediator, lysophosphatidic acid (LPA), exhibits growth factor-like properties and represents an important survival factor in serum. This potent mesangial cell mitogen is increased in conditions associated with glomerular injury. It is also a known activator of the classic mitogen-activated protein kinase (MAPK) pathway, which plays an important role in the regulation of mesangial cell hexokinase (HK) activity. To better understand the mechanisms… CONTINUE READING