LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance.

@article{Yin2005LPAAS,
  title={LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance.},
  author={Fei Yin and Mitchell A. Watsky},
  journal={Investigative ophthalmology & visual science},
  year={2005},
  volume={46 6},
  pages={1927-33}
}
PURPOSE To determine whether lysophosphatidic acid (LPA) or sphingosine-1-phosphate (S1P) affects transcellular resistance across cultured rabbit corneal epithelial and endothelial cells. METHODS Electric cell-substrate impedance sensing (ECIS) was used to measure electrical resistance across cultured rabbit corneal epithelial and endothelial monolayers. After a 1-hour equilibration period, different concentrations of LPA or S1P were added to each well, and the effect observed for 4 hours… CONTINUE READING

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