LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

  title={LOX-1 in atherosclerosis: biological functions and pharmacological modifiers},
  author={Suowen Xu and Sayoko Ogura and Jiawei Chen and Peter J Little and Joel Moss and Peiqing Liu},
  journal={Cellular and Molecular Life Sciences},
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved in endothelial dysfunction, monocyte adhesion, the proliferation, migration, and apoptosis of smooth muscle cells, foam cell formation, platelet activation, as well as plaque instability; all of these events are critical in the pathogenesis of atherosclerosis. These LOX-1-dependent biological processes contribute to… CONTINUE READING


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