LOX-1 and Angiotensin Receptors, and Their Interplay

@article{Wang2011LOX1AA,
  title={LOX-1 and Angiotensin Receptors, and Their Interplay},
  author={Xianwei Wang and Michael Ian Phillips and Jawahar L Mehta},
  journal={Cardiovascular Drugs and Therapy},
  year={2011},
  volume={25},
  pages={401-417}
}
The renin-angiotensin system (RAS) plays an important role in regulating blood pressure, water-salt balance and the pathogenesis of cardiovascular diseases. Angiotensin II (Ang II) is the physiologically active mediator and mediates the main pathophysiological actions in RAS. Ang II exerts the effects by activating its receptors, primarily type 1 (AT1R) and type 2 (AT2R). Most of the known pathophysiological effects of Ang II are mediated by AT1R activation. The precise physiological function… CONTINUE READING

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