LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis.

@article{Ding2014LOX1MD,
  title={LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis.},
  author={Zufeng Ding and Shijie Liu and Xianwei Wang and Yao Dai and Magomed Khaidakov and Xiaoyan Deng and Yubo Fan and David Xiang and Jawahar Lal Mehta},
  journal={Cardiovascular research},
  year={2014},
  volume={103 4},
  pages={619-28}
}
AIMS Lectin-like ox-LDL scavenger receptor-1 (LOX-1) and mitochondrial DNA (mtDNA) damage play a key role in a variety of cardiovascular diseases, including atherosclerosis, hypertension, and inflammation. We posited that damaged mtDNA could trigger autophagy and NLRP3 inflammasome activation, and LOX-1 may play a critical role in this process. METHODS AND RESULTS In order to examine this hypothesis, cultured human THP-1 macrophages exposed to lipopolysaccharide (LPS) were applied to study… CONTINUE READING
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