LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes.

@article{Kuramochi1997LOKIA,
  title={LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes.},
  author={Satomi Kuramochi and Tetsuo Moriguchi and Keisuke Kuida and Jin Endo and Kentaro Semba and Eisuke Nishida and Hajime Karasuyama},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 36},
  pages={22679-84}
}
We have identified a new gene, designated lok (lymphocyte-oriented kinase), that encodes a 966-amino acid protein kinase whose catalytic domain at the N terminus shows homology to that of the STE20 family members involved in mitogen-activated protein (MAP) kinase cascades. The non-catalytic domain of LOK does not have any similarity to that of other known members of the family. There is a proline-rich motif with Src homology region 3 binding potential, followed by a long coiled-coil structure… CONTINUE READING
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