LOH at 1p31 (ARHI) and proliferation in lymph node-negative breast cancer.

@article{Janssen2009LOHA1,
  title={LOH at 1p31 (ARHI) and proliferation in lymph node-negative breast cancer.},
  author={Emiel A. M. Janssen and Irene Tveiter{\aa}s \Ovestad and Ivar Skaland and H{\aa}vard S\oiland and Einar Gudlaugsson and Kjell H. Kjellevold and Arne Nysted and Jon-Arne S\oreide and Jan P. A. Baak},
  journal={Cellular oncology : the official journal of the International Society for Cellular Oncology},
  year={2009},
  volume={31 5},
  pages={335-43}
}
BACKGROUND The mitotic activity index (MAI) is a strong prognosticator in node-negative invasive breast cancer patients. Recently, a correlation between the MAI and specific chromosomal aberrations at chromosome 1p was described. METHODS Analysis of MAI, immunohistochemical staining patterns for proliferation-associated phosphohistone H3 (PPH3), phosphorylated ERK1/2, p21, cyclin E, Ki67 and cyclin D1 proteins; and prognosis in 158 adjuvant chemotherapy-treated T1-2N0M0 invasive breast cancer… CONTINUE READING

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