LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability.

Abstract

BACKGROUND AND AIMS Tumor suppressor genes are often located in frequently deleted chromosomal regions of colorectal cancers (CRCs). In contrast to microsatellite stable (MSS) tumors, only few loss of heterozygosity (LOH) studies were performed in microsatellite instable (MSI) tumors, because MSI carcinomas are generally considered to be chromosomally… (More)
DOI: 10.1093/carcin/bgr011

Topics

Cite this paper

@article{Melcher2011LOHAC, title={LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability.}, author={Ralph Melcher and Elena Maria Hartmann and Waltraud Zopf and Sabine Herterich and Philipp Wilke and Ludwig E. M{\"u}ller and Eduard Rosler and Theodor Kudlich and Oliver Hatem Al-Taie and Andreas Rosenwald and Tiemo Katzenberger and Bettina Scholtka and Stefan Seibold and Dorothee Rogoll and Wolfgang M Scheppach and Michael Scheurlen and Hardi Luehrs}, journal={Carcinogenesis}, year={2011}, volume={32 4}, pages={636-42} }