LOCAS – A Low Coverage Assembly Tool for Resequencing Projects

  title={LOCAS – A Low Coverage Assembly Tool for Resequencing Projects},
  author={Juliane D. Klein and Stephan Ossowski and Korbinian Schneeberger and Detlef Weigel and Daniel H. Huson},
  booktitle={PloS one},
MOTIVATION Next Generation Sequencing (NGS) is a frequently applied approach to detect sequence variations between highly related genomes. Recent large-scale re-sequencing studies as the Human 1000 Genomes Project utilize NGS data of low coverage to afford sequencing of hundreds of individuals. Here, SNPs and micro-indels can be detected by applying an alignment-consensus approach. However, computational methods capable of discovering other variations such as novel insertions or highly diverged… CONTINUE READING
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