LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

@article{Edwards1988LOCALISATIONO1,
  title={LOCALISATION OF 11$\beta$-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR},
  author={Christopher R. W. Edwards and D. Burt and M. A. Mcintyre and E. Ronald de Kloet and P. M. Stewart and L P Brett and W. S. Sutanto and Carl Monder},
  journal={The Lancet},
  year={1988},
  volume={332},
  pages={986-989}
}
In vitro the mineralocorticoid receptor is non-specific and does not distinguish between aldosterone and cortisol. In vivo certain tissues with this receptor are aldosterone selective (eg, kidney and parotid) whereas others with the same receptor are not (eg, hippocampus and heart). Experiments in rats showed that 11 beta-hydroxysteroid dehydrogenase (which converts cortisol to cortisone in man and corticosterone to 11-dehydrocorticosterone in the rat) was much more highly concentrated in… Expand
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